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| Baltimore Orioles — Last 10 | 7-3 Away: 19-26 |
| Houston Astros — Last 10 | 4-6 Home: 23-25 |
| Travel Risk | Low |
| Rest Advantage | Neutral |
| Baltimore Orioles Bullpen (L3D) | 1 games Low fatigue |
| Houston Astros Bullpen (L3D) | 1 games Low fatigue |
AI review runs at pick publication time.