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| Boston Red Sox — Last 10 | 8-2 Away: 24-21 |
| Chicago White Sox — Last 10 | 5-5 Home: 28-15 |
| Travel Risk | High |
| Rest Advantage | Neutral |
| Boston Red Sox Bullpen (L3D) | 2 games Medium fatigue |
| Chicago White Sox Bullpen (L3D) | 2 games Medium fatigue |
AI review runs at pick publication time.