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| Cleveland Guardians — Last 10 | 3-7 Away: 28-28 |
| Cincinnati Reds — Last 10 | 6-4 Home: 23-29 |
| Travel Risk | High |
| Rest Advantage | Neutral |
| Cleveland Guardians Bullpen (L3D) | 3 games High fatigue |
| Cincinnati Reds Bullpen (L3D) | 3 games High fatigue |
AI review runs at pick publication time.