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| Houston Astros — Last 10 | 7-3 Away: 29-28 |
| San Diego Padres — Last 10 | 7-3 Home: 32-25 |
| Travel Risk | Low |
| Rest Advantage | Neutral |
| Houston Astros Bullpen (L3D) | 2 games Medium fatigue |
| San Diego Padres Bullpen (L3D) | 3 games High fatigue |
AI review runs at pick publication time.