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| Pittsburgh Pirates — Last 10 | 7-3 Away: 24-23 |
| Cleveland Guardians — Last 10 | 6-4 Home: 24-23 |
| Travel Risk | Low |
| Rest Advantage | Unknown |
| Pittsburgh Pirates Bullpen (L3D) | 0 games Low fatigue |
| Cleveland Guardians Bullpen (L3D) | 0 games Low fatigue |
AI review runs at pick publication time.