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| San Diego Padres — Last 10 | 7-3 Away: 28-31 |
| Cleveland Guardians — Last 10 | 3-7 Home: 28-31 |
| Travel Risk | Low |
| Rest Advantage | Neutral |
| San Diego Padres Bullpen (L3D) | 2 games Medium fatigue |
| Cleveland Guardians Bullpen (L3D) | 3 games High fatigue |